No. 5 Ohio State bounced back from a 24-23 road loss at Texas with a 42-19 win over Illinois in Week 4 behind junior Julian Say. Now, the Buckeyes (3-1) head to Iowa City in Week 5 as heavy road favorites. Iowa (4-0, 1-0 Big Ten) has been one of the surprises of the 2026 season, going 4-0, including a 20-19 road win at Michigan last week. Claim the latest Polymarket promo code CBSSPORTS to get a $25 bonus after you deposit $10:
Kickoff is set for 3:30 PM ET at Kinnick Stadium in Iowa City, Iowa on CBS and Paramount+. Ohio State is a 14.5-point favorite in the latest Ohio State vs. Iowa odds, with an over/under of 45.5 points. Before choosing between any Ohio State vs. Iowa State, check out the Ohio State vs. Iowa State projections from the SportsLine Projection Model.
Ohio State vs. Iowa quotient
Ohio State spread against Iowa State | Ohio State -14.5 |
Ohio State over/under Iowa State | 45.5 points |
Ohio State vs Iowa money line | Ohio State -625, Iowa +500 |
Ohio State vs. Iowa State | Check out the picks at SportsLine |
Ohio State vs. Iowa broadcast | Paramount+ |
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Best Ohio State vs. Iowa State predictions
Here’s the SportsLine model after simulating Ohio State vs. Iowa 10,000 times It goes below 45.5 points betting programs. Iowa’s last game was under the total for the Hawkeyes this season, and three of the last four games were under the total.
Iowa’s defense has been stingy all season, allowing just 16 points in the opener against Northern Illinois and 13 at Iowa State, and Kirk Ferentz’s teams have a long history of handling low-scoring affairs at Kinnick Stadium. The model projects Iowa to keep this game close defensively and limit Ohio State’s scoring opportunities in a controlled, slow-paced environment. The advanced model calls for 44 combined points because the Under hits 52% of the time. Check out the model spread and moneyline options at SportsLine.
How to pick Ohio State vs. Iowa State
In addition to going “Under” overall, the model also says that one side of the spread hits more than 50% of the time. You can only get the option at SportsLine.
So who wins Ohio State vs. Iowa and which side of the spread hits more than 50% of the simulations? Tune in to SportsLine now and find out to see which side of the spread will move from the leading model at 34-25 runs on top-rated CFB picks.
Why should you trust the SportsLine model?
The model simulates each FBS game 10,000 times. He enters Week 5 with a 32-24 run across all highly rated college football picks on betting sites, returning about $600 for a $100 player. Anyone following his choices college football betting sites could see strong returns.