Week 4 NFL schedule, 49ers vs. Broncos, Raiders vs. Featuring the Chiefs and Seahawks vs. Chargers, it provides an interesting window into the afternoon. Las Vegas and Kansas City head into this AFC West matchup undefeated, and one of SportsLine’s experts is backing the Raiders as the 4.5-point home spread. Chiefs quarterback Patrick Mahomes, who has thrown seven touchdowns this season, is priced at -147 ($147 risk to win $100) to throw 2+ touchdowns against Las Vegas. The pundits also released the NFL’s best bets for Sunday afternoon’s two other matchups.
Be sure to check out the top NFL betting picks from SportsLine’s team of proven experts before locking down your Week 4 NFL picks. New users can also target latest DraftKings promo codeoffers $150 in bonus bets after your first $5 bet:
Week 4 NFL best bets (odds subject to change):
- Raiders (+4.5) vs. Chiefs
- Broncos (+3) and 49ers
- Seahawks (-6.5) vs. Chargers
Putting the experts’ three picks together in Week 4 of the NFL would result in a +613 payout ($100 risk to win $613). Bet now on FanDuel Sportsbook and get up to $250 in bonus bets:
Raiders (+4.5) vs. Chiefs
“Kansas City faces an unusual schedule in 2025 — they’ve never had to play two straight road games in back-to-back weeks unless they have a bye in between,” SportsLine expert Jeff Hochman said. “The last time the Chiefs went on the road for back-to-back games without extra rest was back in November 2024. Las Vegas is averaging 13.0 yards per punt, fourth in the NFL. The Raiders’ defensive front has quietly put up strong numbers. With Jackson Powers-Johnson likely to miss time, the Raiders are counting on Caleb Rogers to be a solid replacement at right guard.”
Broncos (+3) and 49ers
“The Broncos’ offense followed a familiar pattern Sunday, seemingly relearning how to play football in the first half before rallying to win,” SportsLine pundit RJ White said. “I’d normally like to knock off a team like this on the road next week, but this 49ers team is so destroyed that I see a 3-pointer against Denver as a value for a playoff-caliber team. Nick Bosa’s absence was felt last week as the Cardinals moved the ball consistently, and the 49ers have a number of injuries. The Broncos are an above-average team — and I think they are — with the 49ers getting beat like this, this line makes no sense.”
Seahawks (-6.5) vs. Chargers
“I’m not sure I understand that line one bit,” White said. “The Chargers won’t be able to cover them with a terrible Bills performance, turning five Buffalo giveaways into a one-touchdown day. An elite Seahawks team needs to focus after losing a game they should have won after dominating with a +2.8 yards per play differential. I’m not sure the Seahawks are even the best teams in football now that Sam Darnold is back. A line of -10 would make more sense than sub-7, so the oddsmakers finally that they had to believe they’d catch a big break to make it that low, and it didn’t matter that the Seahawks were here.
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